Contrahelicase activity of the mitochondrial transcription termination factor mtDBP

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Contrahelicase activity of the mitochondrial transcription termination factor mtDBP

The sea urchin mitochondrial D-loop binding protein (mtDBP) is a transcription termination factor that is able to arrest bidirectionally mitochondrial RNA chain elongation. The observation that the mtDBP binding site in the main non-coding region is located in correspondence of the 3' end of the triplex structure, where the synthesis of heavy strand mitochondrial (mt) DNA is either prematurely ...

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Sea urchin mtDBP is a two-faced transcription termination factor with a biased polarity depending on the RNA polymerase.

The sea urchin mitochondrial displacement (D)-loop binding protein mtDBP has been previously identified and cloned. The polypeptide (348 amino acids) displays a significant homology with the human mitochondrial transcription termination factor mTERF. This similarity, and the observation that the 3' ends of mitochondrial RNAs coded by opposite strands mapped in correspondence of mtDBP-binding si...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2005

ISSN: 0305-1048,1362-4962

DOI: 10.1093/nar/gki693